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专利名称：Lowered affinity antibodies and uses
therefor
发明人：Hsiu-Ching Chang申请号：US13146805申请日：20100129公开号：US08530629B2公开日：20130910
摘要：The present invention provides novel, rationally designed lowered affinityantibodies for use in various in vivo and in vitro applications. The antibodies of the presentinvention have variable domains that have been designed to reduce or eliminate theantigen binding activity of the parental antibody without altering the overall 3
dimensional antibody structure. Using the antibodies of the present invention in variousassays allows researchers to distinguish effects that result from specific antigen-antibodyinteractions from other, non-specific antibody effects.
申请人：Hsiu-Ching Chang
地址：Lexington MA US
国籍：US
代理机构：K&L Gates LLP
代理人：John M. Garvey,Pei Wu
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