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专利名称：IMPROVED METHODS FOR THE ACYLATION
OF MAYTANSINOL
发明人：WIDDISON, Wayne C.,ZHAO, Robert Yongxin申请号：EP13774881.0申请日：20130926公开号：EP2900676A1公开日：20150805
摘要：Disclosed is a method of preparing an amino acid ester of maytansinol byreacting maytansinol with an N-carboxyanhydride of an amino acid (NCA) in the presenceof a drying agent. Also disclosed is an improved method of preparing an amino acid esterof maytansinol in which a nucleophile is added to the reaction mixture after completionof the reaction between maytansinol and an N-carboxyanhydride of an amino acid.
申请人：ImmunoGen, Inc.
地址：830 Winter Street Waltham, MA 02451 US
国籍：US
代理机构：McNab, Donald C.
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